Magnesium is an essential mineral vital in hundreds of biochemical processes in the body. It involves muscle and nerve function, energy production, protein synthesis, and bone health. With various forms of magnesium supplements available, it can be challenging to determine which one best suits your needs. Two of the most commonly used forms are magnesium citrate and magnesium glycinate. But how do they compare? Which one should you choose? This article provides a detailed comparison of magnesium citrate vs glycinate, exploring their benefits, absorption rates uses, and potential side effects to help you make an informed decision.
What Is Magnesium Citrate?
Magnesium citrate is a compound that consists of magnesium and citric acid. It is one of the most commonly used forms of magnesium due to its relatively high bioavailability and effectiveness in addressing specific health conditions. Because citric acid enhances magnesium absorption, magnesium citrate is often used to treat constipation, as it has a natural laxative effect.
Benefits of Magnesium Citrate
- Supports Digestive Health: Magnesium citrate is widely known for promoting bowel movements. It works as an osmotic laxative, drawing water into the intestines, softening stools, and aiding in regularity.
- Enhances Magnesium Absorption: This form is more bioavailable than magnesium oxide, making it a popular choice for those needing a reliable magnesium supplement.
- Helps Prevent Kidney Stones: Some studies suggest that magnesium citrate may help prevent kidney stone formation by reducing oxalate levels in urine.
- Relieves Muscle Cramps and Spasms: Since magnesium is essential for muscle function, supplementing with magnesium citrate may help alleviate muscle cramps and spasms.
- Improves Heart Health: Magnesium is crucial for cardiovascular health, and some research suggests that magnesium citrate may help regulate blood pressure.

What Is Magnesium Glycinate?
Magnesium glycinate, also known as magnesium bisglycinate, is a form of magnesium bound to glycine, an amino acid with calming properties. This form is highly bioavailable and is often recommended for individuals who need a gentle magnesium supplement without gastrointestinal side effects.
Benefits of Magnesium Glycinate
- Highly Absorbable: Magnesium glycinate is one of the best-absorbed forms of magnesium, making it an excellent choice for individuals with magnesium deficiencies.
- Supports Relaxation and Sleep: Glycine has calming effects on the brain, making magnesium glycinate a popular choice for reducing stress and anxiety and improving sleep quality.
- Reduces Muscle Tension: This magnesium may help ease muscle tension, making it ideal for chronic pain or muscle tightness.
- Beneficial for Mental Health: Studies suggest that magnesium glycinate may support mental well-being by helping to regulate neurotransmitters associated with mood stabilization.
- Gentle on the Stomach: Unlike magnesium citrate, magnesium glycinate has no laxative effect, making it suitable for individuals with sensitive digestive systems.
Magnesium Citrate vs Glycinate: Key Differences
1. Absorption Rate
Both magnesium citrate and magnesium glycinate are well-absorbed by the body. However, magnesium glycinate is considered to have higher bioavailability due to its amino acid chelation, allowing for better uptake at the cellular level.
2. Best For Digestive Health vs. Best for Relaxation
- Magnesium Citrate: Best for digestive issues, particularly constipation relief.
- Magnesium Glycinate: Best for relaxation, anxiety relief, and sleep support.
3. Effects on the Digestive System
- Magnesium Citrate is a mild laxative often used as a natural remedy for constipation.
- Magnesium Glycinate: This does not cause a laxative effect and is easier on the stomach.
4. Best for Muscle Function
Both forms support muscle function, but:
- Magnesium Citrate is ideal for preventing muscle cramps caused by dehydration or electrolyte imbalances.
- Magnesium Glycinate is better for chronic muscle tension and pain due to its calming properties.
5. Use in Treating Deficiencies
Both forms effectively treat magnesium deficiency, but magnesium glycinate is often preferred for long-term supplementation because it is gentler on the stomach and provides neurological benefits.
Who Should Take Magnesium Citrate?
Magnesium citrate may be the best choice if you:
- Struggle with constipation and need a gentle laxative.
- Want a supplement that is affordable and widely available?
- Need general magnesium supplementation with moderate absorption.
- Experience occasional muscle cramps and need magnesium for electrolyte balance.
Who Should Take Magnesium Glycinate?
Magnesium glycinate is recommended if you:
- Experience stress, anxiety, or insomnia and need a calming supplement.
- Have sensitive digestion and want a magnesium supplement without laxative effects.
- Need high absorption and long-term magnesium supplementation.
- Suffer from chronic muscle tension or pain and need a supplement that helps with relaxation.
Potential Side Effects
While both forms of magnesium are generally safe, taking excessive amounts can lead to side effects:
- Magnesium Citrate: This can cause diarrhoea, dehydration, and electrolyte imbalances if taken in large doses.
- Magnesium Glycinate: In very high doses, it may cause drowsiness or low blood pressure, but it is generally well tolerated.
Recommended Dosage
The recommended daily intake (RDI) of magnesium varies by age and gender:
- Men: 400-420 mg per day
- Women: 310-320 mg per day
The magnesium citrate and glycinate dosages depend on the supplement’s specific formulation. Always follow the recommended dosage on the label or consult a healthcare professional.

Conclusion: Which One Should You Choose?
The choice between magnesium citrate vs glycinate depends on your health goals:
- If you need help with constipation, kidney stones, or mild muscle cramps, magnesium citrate may be the better option.
- Magnesium glycinate is the superior choice if you need a supplement for stress relief, better sleep, and muscle relaxation.
Both forms provide essential magnesium benefits, and you may even consider using both at different times depending on your needs. Always consult your doctor before starting any new supplement to ensure it meets your health requirements.
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